Peer Reviewed Publications (Published)

Kaufman CL, Ouseph R, Blair B, Kutz JE, Tsai TM, Scheker LR, Tien HY, Moreno R, Ozyurekoglu T, Banegas, Murphy E, Burns CB, Zaring R, Cook DF, and Marvin MR:  Graft Vasculopathy in Clinical Hand Transplantation.  American Journal of Transplantation, planned for February, 2012

 

Kaufman CL, Breidenbach WC:  World Experience after More Than a Decade of Clinical Hand Transplantation: Update from the Louisville Hand Transplant Program.  Hand Clinics 27 (4) 417-421, November 2011

 

Banegas R, Moreno R, Duggal A, Breidenbach WC:  Surgical Aspects of Donor Hand Transplantation. Journal of Reconstructive Microsurgery, August 22, 2011

 

Schneeberger S, Landin L, Kaufman CK, Gorantla VS, Brandacher G, Cavadas P, Lee WP, Breidenbach WC, Margreiter, Alemtuzumab R: Key for Minimization of Maintenance Immunosuppression in Reconstructive Transplantation?  Transplant Proc. 41 (2): 499-502, 2009.

 

Kaufman CK, Blair, B, Murphy, Erin, Breidenbach, WC:  A New Option for Amputees:  Transplantation of the Hand.  Journal of Rehabilitation Research & Development, Volume 46, Number 3, 2009:  395-404

 

Frey SH, Bogdonav S, Smith, JC, Waltrous S, Breidenbach WC: Chronically deafferented sensory cortex recovers a grossly typical organization after allogenic hand transplantation. Curr. Biology 2008 Oct 14;18 (19): 1530-4

Ravindra, KV, Buell JF, Kaufman C, Blair B, Marvin M, Nagubandi R, Breidenbach WC: Hand transplantation in the United States: experience with 3 patients. Surgery, 2008 Oct; 144(4): 638-43; discussion 643-4

Swearingen B, Ravindra K, Xu H, Wu S, Breidenbach WC, Ildstad ST: Science of composite tissue allotransplantation. Transplantation. 2008 Sept 15;86(5): 627-35

Petruzzo P, Lanzetta M, Dubernard JM, Margreiter R, Schuind F, Breidenbach WC, Nolli R, Schneebergeer S, van Holder C, Kaufman C, Jablecki J, Landin L, Cavadas, P: The international registry on hand and composite tissue transplantation. Transplantation. 2008 Aug 27;86(4): 487-92

Breidenbach WC, Gonzales NR, Kaufman C, Klapheke M, Tobin, GR, Gorantla, VS: Outcomes of the First 2 American Hand Transplants at 8 and 6 Years Posttransplant. Journal of Hand Surgery 33A (7): 1039-1047, 2008

G. R. Tobin, W. C. Breidenbach, D. J. Pidwell, S. T. Ildstad, and K. V. Ravindra. Transplantation of the hand, face, and composite structures: evolution and current status. Clinics in Plastic Surgery 34 (2):271-278, 2007.

Adamson LA, Huang WC, Breidenbach WC, Rahhal D, Xu H, Huang Y, Pidwell DJ, Wei FC, Tobin G, Ildstad ST. A modified model of hindlimb osteomyocutaneous flap for the study of tolerance to composite tissue allografts. Microsurgery. 2007;27(7):630-6. PMID: 17868137 [PubMed - in process]

Lanzetta M, Petruzzo P, Dubernard JM, Margreiter R, Schuind F, Breidenbach W, Nolli R, Schneeberger S, van Holder C, Gorantla VS, Pei G, Zhao J, Zhang X. Second report (1998-2006) of the International Registry of Hand and Composite Tissue Transplantation. Transpl Immunol. 2007 Jul;18(1):1-6. Epub 2007 Apr 9.

Amirlak B, Gonzalez R, Gorantla V, Breidenbach WC 3rd, Tobin GR. Creating a hand transplant program. Clin Plast Surg. 2007 Apr;34(2):279-89, x. Review. PMID: 17418677 [PubMed - indexed for MEDLINE] PMID: 17584595 [PubMed - indexed for MEDLINE]

Tobin GR, Breidenbach WC 3rd, Pidwell DJ, Ildstad ST, Ravindra KV. Transplantation of the hand, face, and composite structures: evolution and current status. Clin Plast Surg. 2007 Apr;34(2):271-8, ix-x. Review. PMID: 17418676 [PubMed - indexed for MEDLINE]

Lanzetta M, Petruzzo P, Margreiter R, Dubernard JM, Schuind F, Breidenbach W, Lucchina S, Schneeberger S, van Holder C, Granger D, Pei G, Zhao J, Zhang X. The International Registry on Hand and Composite Tissue Transplantation. Transplantation. 2005 May 15;79(9):1210-4. PMID: 15880072 [PubMed - indexed for MEDLINE]

Tobin GR, Breidenbach WC, Klapheke MM, Bentley FR, Pidwell DJ, Simmons PD. Ethical considerations in the early composite tissue allograft experience: a review of the Louisville Ethics Program. Transplant Proc. 2005 Mar;37(2):1392-5. Review. PMID: 15848730 [PubMed - indexed for MEDLINE]

Kvernmo HD, Gorantla GS, Gonzalez RN, Breidenbach WC. Hand Transplant: A future clinical option? Acta Orthopaedica, February 2005, Vol. 76, No 1.

Gorantla VS, Gonzalez RN, Breidenbach WC. Hand and Composite Tissue Allotransplantation - Past, Present and Future; The Mutilated Hand, Eds. Weinzweig and Weizweig, Elsevier, Philadelphia, 2005.

Kvernmo HD, Gorantla VS, Gonzalez RN, Breidenbach WC III. Hand Transplantation: A Future Clinical Option? Acta Orthoped. Scand. 76(1): 14-28, 2005.

Brouha PC, Perez-Abadia G, Francois CG, Laurentin-Perez LA, Gorantla V, et. al. Lymphadenectomy prior to rat hind limb allotransplantation prevents graft-versus-host disease in chimeric hosts. Transpl Int. 17(7):341-50, 2004.

Prabhune KA, Gorantla VS, Perez-Abadia G et. al. Composite Tissue Allotransplantation in Chimeric Hosts Part II. A Clinically Relevant Protocol to Induce Tolerance in a Rat Model. Transplantation 76(11):1548-55, 2003.

Pidwell DJ, Gorantla VS, Gonzales RN et. al. Composite Tissue Transplantation: Tolerance through Hematopoietic Chimerism. Human Immunology 64(10 S):S115, 2003.

Gorantla VS, Prabhune KA, Perez-Abadia G, Ildstad ST, Maldonado C, Orhun HI, Majzoub RK, Francois CG, Kakoulidis TP, Brouha PC, Anderson GL, Pidwell DJ, Breidenbach WC, Barker JH. Composite Tissue Allotransplanation in Chimeric Hosts: Part I. Prevention of Graft-Versus-Host Disease. Transplantation, 2003, 75(7), 922-932.

Perez-Abadia G, Laurentin-Perez L., Gorantla VS, Francois CG, Vossen M, Brouha PC, Orhun HI Anderson GL, Maldonado C, Pidwell DJ, Breidenbach WC, Barker JH. Low-dose immunosuppression in a rat hind limb transplantation model. Transplant International, 2003 Aug. 2

Gibbons RD, Duan N, Meltzer D, Pope A, Penhoet ED, Dubler NN, Francis C, Gill B, Guinan E, Henderson M, Ildstad ST, King PA, Martinez-Maldonado M, McLain GE, Murray J, Nelkin D, Spellman MW, Pitluck S; Institute of Medicine Committee. Waiting for organ transplantation: results of an analysis by an Institute of Medicine Committee. Biostatistics. 2003 Apr;4(2):207-22

Fernandez-Botran R, Gorantla VS, Sun X et. al. Targeting of Glycosaminoglycan-Cytokine Interactions as a Novel Therapeutic Approach in Allotransplantation. Transplantation 74(5):623-629, 2002.

Edelstein J, Jones JW, Ren X, Ustuner T, Zdichavsky M, Perez-Abadia G, Granger DK, Jevans AW, Maldonado C, Breidenbach W, Barker JH, Gruber SA. Donor/recipient Skin and Whole-Blood Cyclosporin A Levels in a Swine Composite Tissue Allograft Model: Correlation and Relationship to Rejection. Transplant Procedures, 2002, 34(4), 1315-1319.

Breidenbach WC, Tobin GR, Gorantla VS, Gonzalez RN, Granger DK. A Position Statement in Support of Hand Transplantation. Journal of Hand Surgery, 2002, 27(5), 760-770.

Mueller YM, Cramer DE, Huang Y, Exner BG, Ildstad ST. Hematopoietic stem cells from the marrow of mice treated with Flt3 Ligand are significantly expanded but exhibit reduced engraftment potential. Transplantation. 2002 Apr 27;73(8):1177-85

Xu H, Exner BG, Cramer DE, Tanner MK, Mueller YM, Ildstad ST. CD8(+) alphabeta-TCR(+), and gammadelta-TCR(+) cells in the recipient hematopoietic environment mediate resistance to engraftment of allogeneic donor bone marrow. J Immunol. 2002 Feb 15; 168(4)1636-43.

Brouha PCR, Perez-Abadia G, Francois CG, Gorantla VS, Vossen M, Laurentin-Perez L, Maldonado M, Anderson G, Kon M, Barker JH. Prevention of Graft versus Host Disease in Chimeric Hosts by Lymph Node Removal Prior to Hind Limb Allotransplantation. Journal of American College of Surgeons 52: 527-529, 2001.

Frank J, Gorantla VS, Anderson GL, Laurentin-Perez L, Maldonado C, Barker JH. Microcirculation Research for Microsurgeons - Basic Concepts and Potential Applications. European Journal of Trauma, 27 (4):153-62, 2001.

Vossen M, Gorantla VS, Perez-Abadia G, Brouha PCR, Francois CG, Laurentin-Perez L, Pidwell DJ, Maldonado CJ, Breidenbach WC, Kon M, Barker JH. Vascularized Bone Marrow Transplantation: Fact or Fiction? Surgical Forum, 2001, 52, 526-527.

Tobin GR, Granger DK, Breidenbach WC. Hand Transplantation Follow-Up. The Lancet, 2001, 358: 1018.

Gorantla VS, Perez-Abadia G, Ren X, Majzoub R, Prabhune KA, Francois CG, Vossen M, Brouha PC, Maldonado C, Pidwell DJ, Breidenbach WC, Granger DK, Barker JH. A clinically feasible protocol to induce tolerance to limb allografts using mixed allogeneic chimerism. Abstract #781, Am J Transplant 1(1):321, 2001.

Cendales LC, Breidenbach WC, Granger DK. Successful composite tissue transplantation - nerve and functional recovery after two years. Abstract #1323, Am J Transplant 1(1):471, 2001.

Tobin GR, Granger DK, Breidenbach WC: Hand transplantation follow-up, Lancet 358(9286):1018, 2001.

Edgell S, McCabe SJ, Breidenbach WC, Neace WP, LaJoie AS, Abell TD. Different Reference Frames Can Lead to Different Hand Transplantation Decisions by Patients and Physicians. Journal of Hand Surgery. March 2001, Vol. 26A, No. 2, 196-200.

Edelstein J, Jones JW, Ren X, Ustuner E, Zdichavsky M, Perez-Abadia GA, Granger D, Jevans AW, Maldonado C, Breidenbach WC, Barker JH, Gruber SA. Donor/Recipient Skin and Whole Blood Cyclosporine A Level Swine Composite Tissue Allografts Model: Correlation and Relationship to Rejection. Transplant International, 2001.

Edgell, S.E., McCabe, S.J., Breidenbach, W.C., Neace, W.P., LaJoie, A.S., Abell, T.D. Different reference frames can lead to different hand transplantation decisions by patients and physicians. 2001 Journal of Hand Surgery, 26A, 196-200.

Breidenbach WC, Cendales L: Hand Transplant: Rationale and Case Report in "Upper Extremity Amputations and Management of Acute Microsurgical Treatment: Prostheses and Rehabilitation", Hand Clinics, WB Saunders. Publication date August 2001.

Huang Y, Cramer DE, Ray MB, Chilton PM, Que X, Ildstad ST. The role of alphabeta- and gammadelta-T cells in allogenic donor marrow on engraftment, chimerism, and graft-versus-host disease. Transplantation. 2001 Dec 27;72(12):1907-14.

Gorantla VS, Maldonado C, Frank J, Barker JH. Composite tissue allotransplantation: Current status and future insights. Eur J Trauma. 2001 27 (6).

Brouha PC, Ildstad ST. Mixed allogeneic chimerism. Past, present, and prospects for the future. Transplantation. 2001 Oct 27;72(8 Sulpp)S36-42.

Cendales LC, Breidenbach WC 3rd. Hand transplantation. Hand Clin. 2001 Aug;17(3);499-510.

Domenick MA, Ildstad ST. Impact of bone marrow transplantation on type I diabetes. World J. Surg. 2001 Apr;25(4):474-80.

Chilton PM, Huang Y, Ildstad ST. Bone marrow cell graft engineering: from bench to bedside. Leuk Lymphoma. 2001 Mar;41(1-2):19-34.

Prabhune KA, Gorantla VS, Maldonado C, Perez-Abadia G, Barker JH, Ildstad ST. Mixed allogeneic chimerism and tolerance to composite tissue allografts. Microsurgery. 2000;20(8):441-7.

Ustuner ET, Majzoub RK, Ren X, Edelstein J, Maldonado C, Perez-Abadia G, Breidenbach WC, Barker JH. Swine composite tissue allotransplant model for preclinical hand transplant studies. Microsurgery. 2000;20(8):400-6.

Francois CG, Breidenbach WC, Maldonado C, Kakoulidis TP, Hodges A, Dubernard JM, Owen E, Pei G, Ren X, Barker JH. Hand transplantation: comparisons and observations of the first four clinical cases. Microsurgery. 2000;20(8):360-71.

Jones JW, Gruber SA, Barker JH, Breidenbach WC. Successful hand transplantation. One-year follow-up. Louisville Hand Transplant Team. New England Journal of Medicine 2000 Aug 17;343(7):468-73.

Huang Y, Ildstad ST< Neipp M, Shirwan H. Mouse xenoantigens contribute to rat T-cell Vbeta repertoire generation in mixed xenogeneic bone marrow chimeras. Immunology. 2000 Jul;100(3):317-25.

Colson YL, Schuchert MJ, Ildstad ST. The abrogation of allosensitization following the induction of mixed allogeneic chimerism. Immunology 2000 Jul 15;165(2):637-44.

Mohiuddin MM, Ildstad ST, DiSesa VJ. Establishment of fully xenogeneic (mouse-->rat) bone marrow chimeras: evidence for normal development and clonal deletion of mouse T cells. Transplantation. 2000 Mar 15;69(5):731-6.

Ren X, Shirbacheh MV, Usunter ET, Zdichavsky M, Edelstein J, Maldonado C, Breidenbach WC, Frank J, Tobin GR, Jones JW, Barker JH. Osteomyocutaneous flap as a preclinical composite tissue allograft: swine model. Microsurgery. 2000;20(3):143-9.

Klapheke, MM, Marcell, C, Creamer B, Taliaferro G, Psychiatric assessment of candidates for hand transplantation: I. Screening, Microsurgery, 2000.

Granger DK, Domenick MA, Ildstad ST: Transplantation Immunology and immunosuppression. In Townsend (ed): Sabiston's Textbook of Surgery. WB Saunders:Philadelphia, PA, 403-427, 2000.

Gruber SA, Shirbacheh MV, Jones JW, Barker JH, Breidenbach WC. Local Drug Delivery to Composite Tissue Allografts. Microsurgery, 2000, 20(8), 407-411.

Ustuner ET, Majzoub RK, Ren X, Edelstein J, Maldonado C, Perez-Abadia G, Breidenbach WC, Barker JH. Swine Composite Tissue Allotransplant Model for Preclinical Hand Transplant Studies. Microsurgery, 2000, 20(8), 400-406.

Francois CG, Breidenbach WC, Maldonado C, Kakoulidis TP, Hodges A, Dubernard JM, Owen E, Pei G, Ren X, Barker JH. Hand Transplantation: Comparisons and Observations of the First Four Clinical Cases. Microsurgery, 2000, 20(8), 360-371.

Weber RA, Breidenbach WC, Brown RE, Jabaley ME, Mass DP. A Randomized Prospective Study of Polyglycolic Acid Conduits for Digital Nerve Reconstruction in Humans. Plastic and Reconstructive Surgery, 2000, 106(5), 1036-1048

Jones JW, Gruber S, Barker J, Breidenbach WC. Successful Hand Transplantation: One Year Follow-up. The New England Journal of Medicine, 2000, 343(7): 468-473.

Ren X, Shirbacheh MV, Ustuner ET, Zdichavsky M, Edelstein J, Maldonado C, Breidenbach WC, Frank J, Tobin GR, Gruber SA, Barker JH. Osteomyocutaneous Flap As A Preclinical Composite Tissue Allograft: Swine Model. Microsurgery, 2000, 20(3), 143-149.

Barker JH, Breidenbach WC, Hewitt CW. Second International Symposium on Composite Tissue Allotransplantation. Introduction. Microsurgery, 2000, 20(8), 359.

Cendales L, Favetto M, Moskal M, Breidenbach WC, Gupta A. A Successful Hand Transplantation. AO Dialogue, 2000, 13(1), 15-16.

Orhun H, Perez-Abadia G, Gorantla V, Voor M, Tseng M, Maldonado C, Anderson GL, Ogden L, Breidenbach WC, Barker JH. Elastic Properties of Bone in Composite Tissue Allotransplantation: The Rat Hind Limb Model. Surgical Forum, 2000, 51, 463-465.

Gorantla V, Perez-Abadia G, Prabhune K, Orhun H, Kakoulidis T, Mazjoub R, Maldonado C, Anderson GL, Ogden L, Breidenbach WC, Ildstad S, Barker JH. Composite Tissue Allograft (CTA): Tolerance Induction Without Graft vs. Host Disease (GvHD). Surgical Forum, 2000, 51, 578-579.

Klapheke, MM, Marcell, C, Assessment of candidates for hand transplantation: I. Screening, Journal of Psychosomatic Research, 48, 281, 2000.

Klapheke, MM, Assessment of candidates for hand transplantation: II. Outcome, Journal of Psychosomatic Reserach, 48, 223, 2000.

Granger DK, Jones JW, Pidwell DJ, Kaufman CL. No evidence of donor antigen hyporesponsiveness, chimersim or GVHD after human hand transplantation. Transplant 69(8):S180,#254, 2000.

Jones JW, Granger DK, Ogden L, Gruber S, Breidenbach WC. Acute rejection in human composite tissue transplantation - case report of a hand transplant. Transplant 69(8):S180, #255, 2000.

Ildstad ST, Herzig R, Kaufman C, Crilley P, Brozena S, McCarthy P, Granger DK, Jones J, Dowling R, Baxter-Lowe LA, Tollerud D, Bentley FR. Summary of a phase II protocol to attempt to induce mixed chimerism and donor-specific tolerance to renal and cardiac allografts. Transplant 69(8):S294, #703, 2000.

Cendales L, Breidenbach WC, Granger DK, Jones JW. Evaluation of function following human hand transplantation. Transplant 69(8):S295, #706, 2000.

Jones JW, Guo S, Granger DK. Cyclosporin A induces phosphorylation of erk in vascular smooth muscle cells. Transplant 69(8):S396, #1080, 2000.

Kaufman CL, Ildstad ST, Granger DK, Jones JW, Herzig RH, Salber K, Bentley FR. Loss and recovery of immature and mature peripheral blood populations following low level TBI and combined kidney/bone marrow transplantation. Transplant 69(8):S402, #1113, 2000.

Gorantla VS, Barker JH, Jones JW, Prabhune K, Maldonado C, Granger DK: Immunosuppressive agents in transplantation: Mechanisms of action and current anti-rejection strategies. Microsurgery 20(8):420-429, 2000.

Gruber SA, Shirbacheh MV, Jones JW, Barker JH, Breidenbach WC. Local Drug Delivery to Composite Tissue Allografts. Microsurgery. 2000;20(8):407-411.

Ustuner ET, Majzoub RK, Ren X, Edelstein J, Maldonado C, Perez-Abadia G, Breidenbach WC, Barker JH. Swine Composite Tissue Allotransplant Model for Preclinical Hand Transplant Studies. Microsurgery . 2000;20(8):400-406.

Colson YL, Abou El-Ezz Ay, Gaines BA, Ildstad ST. Positive and negative selection of alphabet TCR+ T cells in thymectomized adult radiation bone marrow chimeras. Transplantation. 1999 Aug 15;68(3):403-10.

Exner BG, Que X, Mueller YM, Domenick MA, Neipp M, Ildstad ST. Alpha beta TCR+ T cells play a nonredundant role in the rejection of heart allografts in mice. Surgery 1999 Aug; 126(2):121-6.

Jones JW, Ustuner ET, Zdichavsky M, Edelstein J, Ren X, Maldonado C, Ray M, Jevans AW, Breidenbach WC, Gruber SA, Barker JH. Long-Term Survival Of An Extremity Composite Tissue Allograft With FK506-Mycophenolate Mofetil Therapy. Surgery, 1999, 126(2), 384-388.

Shirbaheh MV, Jones JW, Harralson TA, Edelstein J, Tecimer T, Breidenbach WC, Jevans AW, Maldonado C, Barker JH, Gruber SA. Pharmacokinetics of Intra-Arterial Delivery of Tacrolimus to Vascularly Isolated Rabbit Forelimb. Journal of Pharmacology and Experimental Therapeutics., 1999, 289(3), 1196-1201.

Shirbacheh MV, Harralson TA, Jones JW, Breidenbach WC, Jevans AW, Maldonado C, Barker JH, Gruber SA. Pharmacokinetic Advantage of Intra-Arterial Cyclosporin A Delivery to Vascularly Isolated Rabbit Forelimb. II. Dose Dependence. Journal of Pharmacology and Experimental Therapeutics, 1999, 289(3), 1191-1195.

Shirbacheh MV, Ren X, Jones JW, Breidenbach W, Jevans A, Fernandez-Botran GR, Maldonado C, Barker J, Gruber S. Pharmacokinetic Advantage of Intra-Arterial Cyclosporin A Delivery to Vascularly Isolated Rabbit Forelimb. I. The Journal of Pharmacology and Experimental Therapeutics, 1999, 289(3), 1185-1190.

Mueller YM, Davenport C, Ildstad ST. Xenotransplantation: application of disease resistance. Clin Exp Pharmacol Physiol. 1999 Dec;26(12):1009-12.

Jones JW Jr, Ustuner ET, Zdichavsky M, Edelstein J, Ren X, Maldonado C, Ray M, Jevans AV, Breidenbach WC, Gruber SA, Barker JH. Long-term survival of an extremity composite tissue allograft with FK506-mycophenolate mofetil therapy. Surgery 1999 Aug;126(2):384-8.

Neipp M, Gammie JS, Exner BG, Li S, Chambers Wh, Pham SM, Ildstad ST. A partial conditioning approach to achieve mixed chimerism in the rat: depletion of host natural killer cells significantly reduces the amount of total body irradiation required for engraftment. Transplantation. 1999 Aug 15;68(3):369-78.

Neipp M, Exner BG, Maru D, Haber M, Gammie JS, Pham SM, Ildstad ST. T-cell depletion of allogeneic bone marrow using anti-alphabeta TCR monoclonal antibody: prevention of graft-versus-host disease without affecting engraftment potential in rats. Exp Hematol. 1999 May;27(5):860-7.

Exner BG, Domenick MA, Bergheim, M, Mueller YM, Ildstad ST. Clinical applications of mixed chimerism. Ann N Y Acad Sci 1999 Apr 30;872:377-85; discussion 385-6.

Kaufman CL, Ildstad ST. Leukodystrophy and bone marrow transplantation: role of mixed hematopoietic chimerism. Neurochem Res.1999 Apr;24(4):537-49.

Exner BG, Acholonu IN, Bergheim M, Mueller YM, Ildstad ST. Mixed allogeneic chimerism to induce tolerance to solid organ and cellular grafts. Acta Haematol. 1999;101(2):78-81.

Klapheke, MM, Transplantation of the human hand: Psychiatric considerations, Bulletin of the Menninger Clinic, 63, 159-174, 1999.

Klapheke, MM, Composite tissue allotransplantation: Psychiatric considerations in hand or arm transplantation, Psychosomatics, 40, 149-150, 1999.

Zdichavsky M, Jones J, Ustuner TE, Ren X, Edelstein J, Maldonado C, Breidenbach W, Gruber SA, Ray M, and Barker JH. Scoring of skin rejection in a swine composite tissue allograft model T Surg Res 85:1-8, 1999

Shirbacheh MV, Jones JW, Harralson T, Edelstein J, Tecimer T, Breidenbach WC, Jevans AW, Maldonado C, Barker JH and Gruber SA. Pharmacokinetics of intraarterial delivery of tacrolimus to the vascularly-isolated rabbit forelimb. J Pharmacol Exp Thera, 289:1196-1201, 1999. This paper is available online at http://www.jpet.org

Ren XP, Shirbacheh MV, Ustuner ET, Zdichavsky M, Edelstein J, Maldonado C, Breidenbach WC, Frank J, Jones J and Barker JH. Radial forelimb osteomyocutaneous flap as a pre-clinical composite tissue allograft (CTA) model in swine. Microsurgery 1999.

Shirbacheh MV, Ren XP, Jones JW, Breidenbach WC, Jevans AW, Fernandez-Botran R, Maldonado C, Barker JH, and Gruber SA. Pharmacokinetic Advantage of Intraarterial cyclosporin A delivery to the vascularly-isolated rabbit forelimb. I. Model Development, J Pharmacol Exp Ther, 289:1185-90,1999. This paper is available online at www.jpet.org

Ustuner ET, Zdiachavsky M, Ren X, Edelstein J, Maldonado C, Ray M, Jevans AW, Breidenbach WC, Gruber SA, Barker JH, Jones JW. Long-Term Composite Tissue Allograft Survival in a Procine Model with Cyclosporine/Mycophenolate Mofetil Therapy. Transplantation, 1998, 66(12), 1581-1587.

Zdichavsky M, Jones JW, Ustuner ET, Ren X, Edelstein J, Maldonado C, Breidenbach W, Gruber S, Ray M, Barker J. Scoring of Skin Rejection in a Swine Composite Tissue Allograft Model. Journal of Surgical Research, 1998, 85, 1-8.

Shirbacheh, MV, Jones JW, Breidenbach, WC, McCabe S., Barker, JH, Gruber, SA. The Case for Local Immunosuppression in Composite Tissue Allotransplantation. Transplantation Proceedings, 1998, 30(6), 2739-2742.

Klapheke, MM, Psychiatric considerations in hand transplantation, Proceedings of the 22nd European Conference on Psychosomatic Research, Manchester, England., September 3-5, 1998.

McCabe SJ, Rodocker GW, Julliard K, Breidenbach WC, Marcell CA, Shirbacheh MV, Barker JH. Using decision analysis to aid in the introduction of upper extremity transplantation. Transplantation Proceedings, 30(6):2783-86, 1998.

Jones JW, Ustuner TE, Zdichavsky M, Ren XP, Edelstein J, Maldonado C, Jevans A, Ray M, Breidenbach WC, Gruber SA, Barker JH. Long-term composite tissue allograft (CTA) survival in a pig model with FK506/Mycophenolate mofetil (MMF) therapy. Surgery 1998

Editorials/Letters to Editor:

Tobin GR, Breidenbach W, Jones J, Barker JH. Hand transplants expand frontiers. Orthopedics Today (Letter to Editor) (IN PRESS), 1998.

Barker JH, Jones JW, Breidenbach WC. Composite Tissue Transplantation; A Clinical Reality? Transplantation Proceedings (Invited Editor), 30(6):2686-2787, 1998.

Peer Reviewed Publications (Published)

Kaufman CL, Ouseph R, Blair B, Kutz JE, Tsai TM, Scheker LR, Tien HY, Moreno R, Ozyurekoglu T, Banegas, Murphy E, Burns CB, Zaring R, Cook DF, and Marvin MR:  Graft Vasculopathy in Clinical Hand Transplantation.  American Journal of Transplantation, planned for February, 2012

 

Kaufman CL, Breidenbach WC:  World Experience after More Than a Decade of Clinical Hand Transplantation: Update from the Louisville Hand Transplant Program.  Hand Clinics 27 (4) 417-421, November 2011

 

Banegas R, Moreno R, Duggal A, Breidenbach WC:  Surgical Aspects of Donor Hand Transplantation. Journal of Reconstructive Microsurgery, August 22, 2011

 

Schneeberger S, Landin L, Kaufman CK, Gorantla VS, Brandacher G, Cavadas P, Lee WP, Breidenbach WC, Margreiter, Alemtuzumab R: Key for Minimization of Maintenance Immunosuppression in Reconstructive Transplantation?  Transplant Proc. 41 (2): 499-502, 2009.

 

Kaufman CK, Blair, B, Murphy, Erin, Breidenbach, WC:  A New Option for Amputees:  Transplantation of the Hand.  Journal of Rehabilitation Research & Development, Volume 46, Number 3, 2009:  395-404

 

Frey SH, Bogdonav S, Smith, JC, Waltrous S, Breidenbach WC: Chronically deafferented sensory cortex recovers a grossly typical organization after allogenic hand transplantation. Curr. Biology 2008 Oct 14;18 (19): 1530-4

Ravindra, KV, Buell JF, Kaufman C, Blair B, Marvin M, Nagubandi R, Breidenbach WC: Hand transplantation in the United States: experience with 3 patients. Surgery, 2008 Oct; 144(4): 638-43; discussion 643-4

Swearingen B, Ravindra K, Xu H, Wu S, Breidenbach WC, Ildstad ST: Science of composite tissue allotransplantation. Transplantation. 2008 Sept 15;86(5): 627-35

Petruzzo P, Lanzetta M, Dubernard JM, Margreiter R, Schuind F, Breidenbach WC, Nolli R, Schneebergeer S, van Holder C, Kaufman C, Jablecki J, Landin L, Cavadas, P: The international registry on hand and composite tissue transplantation. Transplantation. 2008 Aug 27;86(4): 487-92

Breidenbach WC, Gonzales NR, Kaufman C, Klapheke M, Tobin, GR, Gorantla, VS: Outcomes of the First 2 American Hand Transplants at 8 and 6 Years Posttransplant. Journal of Hand Surgery 33A (7): 1039-1047, 2008

G. R. Tobin, W. C. Breidenbach, D. J. Pidwell, S. T. Ildstad, and K. V. Ravindra. Transplantation of the hand, face, and composite structures: evolution and current status. Clinics in Plastic Surgery 34 (2):271-278, 2007.

Adamson LA, Huang WC, Breidenbach WC, Rahhal D, Xu H, Huang Y, Pidwell DJ, Wei FC, Tobin G, Ildstad ST. A modified model of hindlimb osteomyocutaneous flap for the study of tolerance to composite tissue allografts. Microsurgery. 2007;27(7):630-6. PMID: 17868137 [PubMed - in process]

Lanzetta M, Petruzzo P, Dubernard JM, Margreiter R, Schuind F, Breidenbach W, Nolli R, Schneeberger S, van Holder C, Gorantla VS, Pei G, Zhao J, Zhang X. Second report (1998-2006) of the International Registry of Hand and Composite Tissue Transplantation. Transpl Immunol. 2007 Jul;18(1):1-6. Epub 2007 Apr 9.

Amirlak B, Gonzalez R, Gorantla V, Breidenbach WC 3rd, Tobin GR. Creating a hand transplant program. Clin Plast Surg. 2007 Apr;34(2):279-89, x. Review. PMID: 17418677 [PubMed - indexed for MEDLINE] PMID: 17584595 [PubMed - indexed for MEDLINE]

Tobin GR, Breidenbach WC 3rd, Pidwell DJ, Ildstad ST, Ravindra KV. Transplantation of the hand, face, and composite structures: evolution and current status. Clin Plast Surg. 2007 Apr;34(2):271-8, ix-x. Review. PMID: 17418676 [PubMed - indexed for MEDLINE]

Lanzetta M, Petruzzo P, Margreiter R, Dubernard JM, Schuind F, Breidenbach W, Lucchina S, Schneeberger S, van Holder C, Granger D, Pei G, Zhao J, Zhang X. The International Registry on Hand and Composite Tissue Transplantation. Transplantation. 2005 May 15;79(9):1210-4. PMID: 15880072 [PubMed - indexed for MEDLINE]

Tobin GR, Breidenbach WC, Klapheke MM, Bentley FR, Pidwell DJ, Simmons PD. Ethical considerations in the early composite tissue allograft experience: a review of the Louisville Ethics Program. Transplant Proc. 2005 Mar;37(2):1392-5. Review. PMID: 15848730 [PubMed - indexed for MEDLINE]

Kvernmo HD, Gorantla GS, Gonzalez RN, Breidenbach WC. Hand Transplant: A future clinical option? Acta Orthopaedica, February 2005, Vol. 76, No 1.

Gorantla VS, Gonzalez RN, Breidenbach WC. Hand and Composite Tissue Allotransplantation - Past, Present and Future; The Mutilated Hand, Eds. Weinzweig and Weizweig, Elsevier, Philadelphia, 2005.

Kvernmo HD, Gorantla VS, Gonzalez RN, Breidenbach WC III. Hand Transplantation: A Future Clinical Option? Acta Orthoped. Scand. 76(1): 14-28, 2005.

Brouha PC, Perez-Abadia G, Francois CG, Laurentin-Perez LA, Gorantla V, et. al. Lymphadenectomy prior to rat hind limb allotransplantation prevents graft-versus-host disease in chimeric hosts. Transpl Int. 17(7):341-50, 2004.

Prabhune KA, Gorantla VS, Perez-Abadia G et. al. Composite Tissue Allotransplantation in Chimeric Hosts Part II. A Clinically Relevant Protocol to Induce Tolerance in a Rat Model. Transplantation 76(11):1548-55, 2003.

Pidwell DJ, Gorantla VS, Gonzales RN et. al. Composite Tissue Transplantation: Tolerance through Hematopoietic Chimerism. Human Immunology 64(10 S):S115, 2003.

Gorantla VS, Prabhune KA, Perez-Abadia G, Ildstad ST, Maldonado C, Orhun HI, Majzoub RK, Francois CG, Kakoulidis TP, Brouha PC, Anderson GL, Pidwell DJ, Breidenbach WC, Barker JH. Composite Tissue Allotransplanation in Chimeric Hosts: Part I. Prevention of Graft-Versus-Host Disease. Transplantation, 2003, 75(7), 922-932.

Perez-Abadia G, Laurentin-Perez L., Gorantla VS, Francois CG, Vossen M, Brouha PC, Orhun HI Anderson GL, Maldonado C, Pidwell DJ, Breidenbach WC, Barker JH. Low-dose immunosuppression in a rat hind limb transplantation model. Transplant International, 2003 Aug. 2

Gibbons RD, Duan N, Meltzer D, Pope A, Penhoet ED, Dubler NN, Francis C, Gill B, Guinan E, Henderson M, Ildstad ST, King PA, Martinez-Maldonado M, McLain GE, Murray J, Nelkin D, Spellman MW, Pitluck S; Institute of Medicine Committee. Waiting for organ transplantation: results of an analysis by an Institute of Medicine Committee. Biostatistics. 2003 Apr;4(2):207-22

Fernandez-Botran R, Gorantla VS, Sun X et. al. Targeting of Glycosaminoglycan-Cytokine Interactions as a Novel Therapeutic Approach in Allotransplantation. Transplantation 74(5):623-629, 2002.

Edelstein J, Jones JW, Ren X, Ustuner T, Zdichavsky M, Perez-Abadia G, Granger DK, Jevans AW, Maldonado C, Breidenbach W, Barker JH, Gruber SA. Donor/recipient Skin and Whole-Blood Cyclosporin A Levels in a Swine Composite Tissue Allograft Model: Correlation and Relationship to Rejection. Transplant Procedures, 2002, 34(4), 1315-1319.

Breidenbach WC, Tobin GR, Gorantla VS, Gonzalez RN, Granger DK. A Position Statement in Support of Hand Transplantation. Journal of Hand Surgery, 2002, 27(5), 760-770.

Mueller YM, Cramer DE, Huang Y, Exner BG, Ildstad ST. Hematopoietic stem cells from the marrow of mice treated with Flt3 Ligand are significantly expanded but exhibit reduced engraftment potential. Transplantation. 2002 Apr 27;73(8):1177-85

Xu H, Exner BG, Cramer DE, Tanner MK, Mueller YM, Ildstad ST. CD8(+) alphabeta-TCR(+), and gammadelta-TCR(+) cells in the recipient hematopoietic environment mediate resistance to engraftment of allogeneic donor bone marrow. J Immunol. 2002 Feb 15; 168(4)1636-43.

Brouha PCR, Perez-Abadia G, Francois CG, Gorantla VS, Vossen M, Laurentin-Perez L, Maldonado M, Anderson G, Kon M, Barker JH. Prevention of Graft versus Host Disease in Chimeric Hosts by Lymph Node Removal Prior to Hind Limb Allotransplantation. Journal of American College of Surgeons 52: 527-529, 2001.

Frank J, Gorantla VS, Anderson GL, Laurentin-Perez L, Maldonado C, Barker JH. Microcirculation Research for Microsurgeons - Basic Concepts and Potential Applications. European Journal of Trauma, 27 (4):153-62, 2001.

Vossen M, Gorantla VS, Perez-Abadia G, Brouha PCR, Francois CG, Laurentin-Perez L, Pidwell DJ, Maldonado CJ, Breidenbach WC, Kon M, Barker JH. Vascularized Bone Marrow Transplantation: Fact or Fiction? Surgical Forum, 2001, 52, 526-527.

Tobin GR, Granger DK, Breidenbach WC. Hand Transplantation Follow-Up. The Lancet, 2001, 358: 1018.

Gorantla VS, Perez-Abadia G, Ren X, Majzoub R, Prabhune KA, Francois CG, Vossen M, Brouha PC, Maldonado C, Pidwell DJ, Breidenbach WC, Granger DK, Barker JH. A clinically feasible protocol to induce tolerance to limb allografts using mixed allogeneic chimerism. Abstract #781, Am J Transplant 1(1):321, 2001.

Cendales LC, Breidenbach WC, Granger DK. Successful composite tissue transplantation - nerve and functional recovery after two years. Abstract #1323, Am J Transplant 1(1):471, 2001.

Tobin GR, Granger DK, Breidenbach WC: Hand transplantation follow-up, Lancet 358(9286):1018, 2001.

Edgell S, McCabe SJ, Breidenbach WC, Neace WP, LaJoie AS, Abell TD. Different Reference Frames Can Lead to Different Hand Transplantation Decisions by Patients and Physicians. Journal of Hand Surgery. March 2001, Vol. 26A, No. 2, 196-200.

Edelstein J, Jones JW, Ren X, Ustuner E, Zdichavsky M, Perez-Abadia GA, Granger D, Jevans AW, Maldonado C, Breidenbach WC, Barker JH, Gruber SA. Donor/Recipient Skin and Whole Blood Cyclosporine A Level Swine Composite Tissue Allografts Model: Correlation and Relationship to Rejection. Transplant International, 2001.

Edgell, S.E., McCabe, S.J., Breidenbach, W.C., Neace, W.P., LaJoie, A.S., Abell, T.D. Different reference frames can lead to different hand transplantation decisions by patients and physicians. 2001 Journal of Hand Surgery, 26A, 196-200.

Breidenbach WC, Cendales L: Hand Transplant: Rationale and Case Report in "Upper Extremity Amputations and Management of Acute Microsurgical Treatment: Prostheses and Rehabilitation", Hand Clinics, WB Saunders. Publication date August 2001.

Huang Y, Cramer DE, Ray MB, Chilton PM, Que X, Ildstad ST. The role of alphabeta- and gammadelta-T cells in allogenic donor marrow on engraftment, chimerism, and graft-versus-host disease. Transplantation. 2001 Dec 27;72(12):1907-14.

Gorantla VS, Maldonado C, Frank J, Barker JH. Composite tissue allotransplantation: Current status and future insights. Eur J Trauma. 2001 27 (6).

Brouha PC, Ildstad ST. Mixed allogeneic chimerism. Past, present, and prospects for the future. Transplantation. 2001 Oct 27;72(8 Sulpp)S36-42.

Cendales LC, Breidenbach WC 3rd. Hand transplantation. Hand Clin. 2001 Aug;17(3);499-510.

Domenick MA, Ildstad ST. Impact of bone marrow transplantation on type I diabetes. World J. Surg. 2001 Apr;25(4):474-80.

Chilton PM, Huang Y, Ildstad ST. Bone marrow cell graft engineering: from bench to bedside. Leuk Lymphoma. 2001 Mar;41(1-2):19-34.

Prabhune KA, Gorantla VS, Maldonado C, Perez-Abadia G, Barker JH, Ildstad ST. Mixed allogeneic chimerism and tolerance to composite tissue allografts. Microsurgery. 2000;20(8):441-7.

Ustuner ET, Majzoub RK, Ren X, Edelstein J, Maldonado C, Perez-Abadia G, Breidenbach WC, Barker JH. Swine composite tissue allotransplant model for preclinical hand transplant studies. Microsurgery. 2000;20(8):400-6.

Francois CG, Breidenbach WC, Maldonado C, Kakoulidis TP, Hodges A, Dubernard JM, Owen E, Pei G, Ren X, Barker JH. Hand transplantation: comparisons and observations of the first four clinical cases. Microsurgery. 2000;20(8):360-71.

Jones JW, Gruber SA, Barker JH, Breidenbach WC. Successful hand transplantation. One-year follow-up. Louisville Hand Transplant Team. New England Journal of Medicine 2000 Aug 17;343(7):468-73.

Huang Y, Ildstad ST< Neipp M, Shirwan H. Mouse xenoantigens contribute to rat T-cell Vbeta repertoire generation in mixed xenogeneic bone marrow chimeras. Immunology. 2000 Jul;100(3):317-25.

Colson YL, Schuchert MJ, Ildstad ST. The abrogation of allosensitization following the induction of mixed allogeneic chimerism. Immunology 2000 Jul 15;165(2):637-44.

Mohiuddin MM, Ildstad ST, DiSesa VJ. Establishment of fully xenogeneic (mouse-->rat) bone marrow chimeras: evidence for normal development and clonal deletion of mouse T cells. Transplantation. 2000 Mar 15;69(5):731-6.

Ren X, Shirbacheh MV, Usunter ET, Zdichavsky M, Edelstein J, Maldonado C, Breidenbach WC, Frank J, Tobin GR, Jones JW, Barker JH. Osteomyocutaneous flap as a preclinical composite tissue allograft: swine model. Microsurgery. 2000;20(3):143-9.

Klapheke, MM, Marcell, C, Creamer B, Taliaferro G, Psychiatric assessment of candidates for hand transplantation: I. Screening, Microsurgery, 2000.

Granger DK, Domenick MA, Ildstad ST: Transplantation Immunology and immunosuppression. In Townsend (ed): Sabiston's Textbook of Surgery. WB Saunders:Philadelphia, PA, 403-427, 2000.

Gruber SA, Shirbacheh MV, Jones JW, Barker JH, Breidenbach WC. Local Drug Delivery to Composite Tissue Allografts. Microsurgery, 2000, 20(8), 407-411.

Ustuner ET, Majzoub RK, Ren X, Edelstein J, Maldonado C, Perez-Abadia G, Breidenbach WC, Barker JH. Swine Composite Tissue Allotransplant Model for Preclinical Hand Transplant Studies. Microsurgery, 2000, 20(8), 400-406.

Francois CG, Breidenbach WC, Maldonado C, Kakoulidis TP, Hodges A, Dubernard JM, Owen E, Pei G, Ren X, Barker JH. Hand Transplantation: Comparisons and Observations of the First Four Clinical Cases. Microsurgery, 2000, 20(8), 360-371.

Weber RA, Breidenbach WC, Brown RE, Jabaley ME, Mass DP. A Randomized Prospective Study of Polyglycolic Acid Conduits for Digital Nerve Reconstruction in Humans. Plastic and Reconstructive Surgery, 2000, 106(5), 1036-1048

Jones JW, Gruber S, Barker J, Breidenbach WC. Successful Hand Transplantation: One Year Follow-up. The New England Journal of Medicine, 2000, 343(7): 468-473.

Ren X, Shirbacheh MV, Ustuner ET, Zdichavsky M, Edelstein J, Maldonado C, Breidenbach WC, Frank J, Tobin GR, Gruber SA, Barker JH. Osteomyocutaneous Flap As A Preclinical Composite Tissue Allograft: Swine Model. Microsurgery, 2000, 20(3), 143-149.

Barker JH, Breidenbach WC, Hewitt CW. Second International Symposium on Composite Tissue Allotransplantation. Introduction. Microsurgery, 2000, 20(8), 359.

Cendales L, Favetto M, Moskal M, Breidenbach WC, Gupta A. A Successful Hand Transplantation. AO Dialogue, 2000, 13(1), 15-16.

Orhun H, Perez-Abadia G, Gorantla V, Voor M, Tseng M, Maldonado C, Anderson GL, Ogden L, Breidenbach WC, Barker JH. Elastic Properties of Bone in Composite Tissue Allotransplantation: The Rat Hind Limb Model. Surgical Forum, 2000, 51, 463-465.

Gorantla V, Perez-Abadia G, Prabhune K, Orhun H, Kakoulidis T, Mazjoub R, Maldonado C, Anderson GL, Ogden L, Breidenbach WC, Ildstad S, Barker JH. Composite Tissue Allograft (CTA): Tolerance Induction Without Graft vs. Host Disease (GvHD). Surgical Forum, 2000, 51, 578-579.

Klapheke, MM, Marcell, C, Assessment of candidates for hand transplantation: I. Screening, Journal of Psychosomatic Research, 48, 281, 2000.

Klapheke, MM, Assessment of candidates for hand transplantation: II. Outcome, Journal of Psychosomatic Reserach, 48, 223, 2000.

Granger DK, Jones JW, Pidwell DJ, Kaufman CL. No evidence of donor antigen hyporesponsiveness, chimersim or GVHD after human hand transplantation. Transplant 69(8):S180,#254, 2000.

Jones JW, Granger DK, Ogden L, Gruber S, Breidenbach WC. Acute rejection in human composite tissue transplantation - case report of a hand transplant. Transplant 69(8):S180, #255, 2000.

Ildstad ST, Herzig R, Kaufman C, Crilley P, Brozena S, McCarthy P, Granger DK, Jones J, Dowling R, Baxter-Lowe LA, Tollerud D, Bentley FR. Summary of a phase II protocol to attempt to induce mixed chimerism and donor-specific tolerance to renal and cardiac allografts. Transplant 69(8):S294, #703, 2000.

Cendales L, Breidenbach WC, Granger DK, Jones JW. Evaluation of function following human hand transplantation. Transplant 69(8):S295, #706, 2000.

Jones JW, Guo S, Granger DK. Cyclosporin A induces phosphorylation of erk in vascular smooth muscle cells. Transplant 69(8):S396, #1080, 2000.

Kaufman CL, Ildstad ST, Granger DK, Jones JW, Herzig RH, Salber K, Bentley FR. Loss and recovery of immature and mature peripheral blood populations following low level TBI and combined kidney/bone marrow transplantation. Transplant 69(8):S402, #1113, 2000.

Gorantla VS, Barker JH, Jones JW, Prabhune K, Maldonado C, Granger DK: Immunosuppressive agents in transplantation: Mechanisms of action and current anti-rejection strategies. Microsurgery 20(8):420-429, 2000.

Gruber SA, Shirbacheh MV, Jones JW, Barker JH, Breidenbach WC. Local Drug Delivery to Composite Tissue Allografts. Microsurgery. 2000;20(8):407-411.

Ustuner ET, Majzoub RK, Ren X, Edelstein J, Maldonado C, Perez-Abadia G, Breidenbach WC, Barker JH. Swine Composite Tissue Allotransplant Model for Preclinical Hand Transplant Studies. Microsurgery . 2000;20(8):400-406.

Colson YL, Abou El-Ezz Ay, Gaines BA, Ildstad ST. Positive and negative selection of alphabet TCR+ T cells in thymectomized adult radiation bone marrow chimeras. Transplantation. 1999 Aug 15;68(3):403-10.

Exner BG, Que X, Mueller YM, Domenick MA, Neipp M, Ildstad ST. Alpha beta TCR+ T cells play a nonredundant role in the rejection of heart allografts in mice. Surgery 1999 Aug; 126(2):121-6.

Jones JW, Ustuner ET, Zdichavsky M, Edelstein J, Ren X, Maldonado C, Ray M, Jevans AW, Breidenbach WC, Gruber SA, Barker JH. Long-Term Survival Of An Extremity Composite Tissue Allograft With FK506-Mycophenolate Mofetil Therapy. Surgery, 1999, 126(2), 384-388.

Shirbaheh MV, Jones JW, Harralson TA, Edelstein J, Tecimer T, Breidenbach WC, Jevans AW, Maldonado C, Barker JH, Gruber SA. Pharmacokinetics of Intra-Arterial Delivery of Tacrolimus to Vascularly Isolated Rabbit Forelimb. Journal of Pharmacology and Experimental Therapeutics., 1999, 289(3), 1196-1201.

Shirbacheh MV, Harralson TA, Jones JW, Breidenbach WC, Jevans AW, Maldonado C, Barker JH, Gruber SA. Pharmacokinetic Advantage of Intra-Arterial Cyclosporin A Delivery to Vascularly Isolated Rabbit Forelimb. II. Dose Dependence. Journal of Pharmacology and Experimental Therapeutics, 1999, 289(3), 1191-1195.

Shirbacheh MV, Ren X, Jones JW, Breidenbach W, Jevans A, Fernandez-Botran GR, Maldonado C, Barker J, Gruber S. Pharmacokinetic Advantage of Intra-Arterial Cyclosporin A Delivery to Vascularly Isolated Rabbit Forelimb. I. The Journal of Pharmacology and Experimental Therapeutics, 1999, 289(3), 1185-1190.

Mueller YM, Davenport C, Ildstad ST. Xenotransplantation: application of disease resistance. Clin Exp Pharmacol Physiol. 1999 Dec;26(12):1009-12.

Jones JW Jr, Ustuner ET, Zdichavsky M, Edelstein J, Ren X, Maldonado C, Ray M, Jevans AV, Breidenbach WC, Gruber SA, Barker JH. Long-term survival of an extremity composite tissue allograft with FK506-mycophenolate mofetil therapy. Surgery 1999 Aug;126(2):384-8.

Neipp M, Gammie JS, Exner BG, Li S, Chambers Wh, Pham SM, Ildstad ST. A partial conditioning approach to achieve mixed chimerism in the rat: depletion of host natural killer cells significantly reduces the amount of total body irradiation required for engraftment. Transplantation. 1999 Aug 15;68(3):369-78.

Neipp M, Exner BG, Maru D, Haber M, Gammie JS, Pham SM, Ildstad ST. T-cell depletion of allogeneic bone marrow using anti-alphabeta TCR monoclonal antibody: prevention of graft-versus-host disease without affecting engraftment potential in rats. Exp Hematol. 1999 May;27(5):860-7.

Exner BG, Domenick MA, Bergheim, M, Mueller YM, Ildstad ST. Clinical applications of mixed chimerism. Ann N Y Acad Sci 1999 Apr 30;872:377-85; discussion 385-6.

Kaufman CL, Ildstad ST. Leukodystrophy and bone marrow transplantation: role of mixed hematopoietic chimerism. Neurochem Res.1999 Apr;24(4):537-49.

Exner BG, Acholonu IN, Bergheim M, Mueller YM, Ildstad ST. Mixed allogeneic chimerism to induce tolerance to solid organ and cellular grafts. Acta Haematol. 1999;101(2):78-81.

Klapheke, MM, Transplantation of the human hand: Psychiatric considerations, Bulletin of the Menninger Clinic, 63, 159-174, 1999.

Klapheke, MM, Composite tissue allotransplantation: Psychiatric considerations in hand or arm transplantation, Psychosomatics, 40, 149-150, 1999.

Zdichavsky M, Jones J, Ustuner TE, Ren X, Edelstein J, Maldonado C, Breidenbach W, Gruber SA, Ray M, and Barker JH. Scoring of skin rejection in a swine composite tissue allograft model T Surg Res 85:1-8, 1999

Shirbacheh MV, Jones JW, Harralson T, Edelstein J, Tecimer T, Breidenbach WC, Jevans AW, Maldonado C, Barker JH and Gruber SA. Pharmacokinetics of intraarterial delivery of tacrolimus to the vascularly-isolated rabbit forelimb. J Pharmacol Exp Thera, 289:1196-1201, 1999. This paper is available online at http://www.jpet.org

Ren XP, Shirbacheh MV, Ustuner ET, Zdichavsky M, Edelstein J, Maldonado C, Breidenbach WC, Frank J, Jones J and Barker JH. Radial forelimb osteomyocutaneous flap as a pre-clinical composite tissue allograft (CTA) model in swine. Microsurgery 1999.

Shirbacheh MV, Ren XP, Jones JW, Breidenbach WC, Jevans AW, Fernandez-Botran R, Maldonado C, Barker JH, and Gruber SA. Pharmacokinetic Advantage of Intraarterial cyclosporin A delivery to the vascularly-isolated rabbit forelimb. I. Model Development, J Pharmacol Exp Ther, 289:1185-90,1999. This paper is available online at www.jpet.org

Ustuner ET, Zdiachavsky M, Ren X, Edelstein J, Maldonado C, Ray M, Jevans AW, Breidenbach WC, Gruber SA, Barker JH, Jones JW. Long-Term Composite Tissue Allograft Survival in a Procine Model with Cyclosporine/Mycophenolate Mofetil Therapy. Transplantation, 1998, 66(12), 1581-1587.

Zdichavsky M, Jones JW, Ustuner ET, Ren X, Edelstein J, Maldonado C, Breidenbach W, Gruber S, Ray M, Barker J. Scoring of Skin Rejection in a Swine Composite Tissue Allograft Model. Journal of Surgical Research, 1998, 85, 1-8.

Shirbacheh, MV, Jones JW, Breidenbach, WC, McCabe S., Barker, JH, Gruber, SA. The Case for Local Immunosuppression in Composite Tissue Allotransplantation. Transplantation Proceedings, 1998, 30(6), 2739-2742.

Klapheke, MM, Psychiatric considerations in hand transplantation, Proceedings of the 22nd European Conference on Psychosomatic Research, Manchester, England., September 3-5, 1998.

McCabe SJ, Rodocker GW, Julliard K, Breidenbach WC, Marcell CA, Shirbacheh MV, Barker JH. Using decision analysis to aid in the introduction of upper extremity transplantation. Transplantation Proceedings, 30(6):2783-86, 1998.

Jones JW, Ustuner TE, Zdichavsky M, Ren XP, Edelstein J, Maldonado C, Jevans A, Ray M, Breidenbach WC, Gruber SA, Barker JH. Long-term composite tissue allograft (CTA) survival in a pig model with FK506/Mycophenolate mofetil (MMF) therapy. Surgery 1998

Editorials/Letters to Editor:

Tobin GR, Breidenbach W, Jones J, Barker JH. Hand transplants expand frontiers. Orthopedics Today (Letter to Editor) (IN PRESS), 1998.

Barker JH, Jones JW, Breidenbach WC. Composite Tissue Transplantation; A Clinical Reality? Transplantation Proceedings (Invited Editor), 30(6):2686-2787, 1998.

 

Jewish Hospital & St. Mary's HealthCare Kleinert Institute Kleinert Kutz Hand Care Center University of Louisville School of Medicine